A little ballpark symmetry as Given to Fly opens, just like at Wrigley 2. The Joe Strummer and the Mescaleros cover “Arms Aloft” is the first of two covers in the main set, with the lyric changed to “Arms Aloft/in Fenway Park” instead of Aberdeen. The first of many guest appearances on the night sees famed photographer Danny Clinch join to play harmonica on a fantastic Red Mosquito. Leatherman is scratched from the original setlist in favor of another Yield b-side, U. Following Even Flow, Ed applauds Mike for playing so well while medicated, due to a sinus infection. He then introduces the next one by saying they are going to play it “a little differently” this time. Then, for the first time since the Orpheum in 1994, Ed sings the original lyrics to Immortality:

I could take the sun
Pour a cup to share with everyone
Need to feel some comfort in this world
I won’t take it all
I won’t say that nothing’s not my fault
Cannot feel the future in the wind

I could paint the moon
With the light reflected in my room
All I need’s a mirror for the glare
I could paint the Earth, how
With the love I feel for you and her
Needn’t I to alter in the air

After Immortality, Bill Janovitz from Buffalo Tom is back out for the 2nd night in a row. Bill says it’s “wicked awesome” to be there a second time, and he and Ed trade off lyrics on main set cover #2, Buffalo Tom’s Taillights Fade. During the bridge of Not For You, Ed starts a “Let’s Go Red Sox” chant. Introducing Can’t Deny Me, Ed claims the original title of the song was “Voting Is Your Superpower,” and Mark Guiliana (drummer on Matt Cameron’s solo record Cavedweller) is invited on stage to play cowbell. Ed claims the title of the song was originally “Voting Is Your Superpower.” Jeff adds the bass line from Sweet Emotion at the end of Jeremy, as a nod to Aerosmith bassist Tom Hamilton, who is in attendance. The Betterman tag finds Ed pondering whether he could find a better crowd: “Maybe Philly, that’s a pretty good crowd. New York City, that’s a pretty good crowd. Some nights it just feels like you can’t find a better crowd than Boston, Massachusetts…is tonight one of those nights? Whaddya got?” Coming back out for the encore, Ed says “the next time we play together we’re gonna be in the studio, [this is] the last time we’re gonna be playing in front of people for a while,” and that tonight “we’re gonna play until David Ortiz and Kevin Youkilis [former Red Sox players] come and pull us off the stage.” This prompts Youkilis to take the stage carrying a guitar, holding it in his signature batting stance. Thumbing My Way is a request for a person Matt met, as well as a friend of Ed’s. Ed asks the crowd to hold their phones up to light the stadium for Imagine. Loud “Boooom” chants after Crazy Mary, as Ed mentions Team Hawaii won the Little League World Series and that Boom’s wife is involved with the league on the island. Over the Wasted Reprise bed, Ed says he’ll miss the Monster but hopes to be back in October (the Red Sox would end up winning the World Series). Life Wasted is dedicated to John Martin from the Red Sox video crew, who was stricken with ALS. The ever-elusive Dirty Frank is teased for about 30 seconds before a debut cover, Dirty Water by the Standells.

Band in great spirits from the start. Last line of Sometimes is changed to “You’d like it here…dear god.” After Low Light, Ed mentions Bono “losing his throat” the night before, and thanks him for his work with the Red Campaign and other charitable/philanthropic endeavors, and asks the “Irish” crowd to wish the “Irishman” well. After a blistering Corduroy, driven by Matt, Ed takes a sip of wine and regales the crowd with a speech about the word ‘fuck’:

…you know, it can be used as a noun. Well, it can be used as a verb, which in its best way, you know, is romantic and ‘let’s fuck’. Or it can be insulting like ‘get fucked’…and I’ve got an adjective too…like ’fucking amazing’ like the Red Sox, they’re ‘fucking amazing.’ And anyone from Boston who might be booing, ‘fuck you.’ Or, you can use it as an adjective and a noun ‘you fucking fuck’ or an exclamation, which I’m realizing now because there might be kids in the audience and I’m thinking to myself ‘fuck!’ Sorry, sorry, fuck, sorry.

Before Given to Fly, Ed mentions that this is their 23rd show in Boston and dedicates it to a local named Dick, who worked putting on shows in the area and was recovering from a recent health scare. This version of I Am A Patriot starts off with the slow intro that develops into a raucous performance with a nod to the crowd, presumably full of New England Patriots fans, with Ed proclaiming “this is the one city in the world where you don’t have to introduce this one.” Ed changes into a Red Sox “Vedder 18” jersey during Porch, traversing the front of the crowd. After the first break, Ed brings out a red Fender Telecaster given to him by Tom Petty, saying “this is only the second time that I’ve taken this guitar out of my house, because a few years ago I gave Tom a guitar that he was looking for…and then a couple months later I got this beautiful red Red Sox color Telecaster in the mail from Tom, and he said ‘this was my baby for the last few tours, but I think there’s a few songs in it.’ So I brought it tonight. He played here in 2014 and he was right, there’s some songs in it. Maybe we can get his attention if we light some lights and make this place look like the church that it is for our dear friend Tom. Please sing along with me. I want him to hear. I love you Tom” leading to an emotional I Won’t Back Down. Tremor Christ seems to be added on the spot, Ed: “If I talk to the fellas, can we play a little something we don’t normally play? We’ll try it, if we fuck it up it will be my fault and it won’t be the first time and my wife’s here to attest to that.” After a soaring Black, Ed says that in July of 1991 the band stayed at a Howard Johnson’s across the street, and he and Jeff shared a room together, while Stone and Mike roomed together, and they lit incense and it was “so romantic,” then tells a story of how he snuck into Fenway and took two pictures behind home plate, fulfilling a lifelong dream. Ed comes onstage after the second break wearing a backwards #23 Red Sox batting helmet, and talks about pot being legal in Seattle, and that they rolled one up with something they found called “The Green Monster.” Bill Janovitz of Buffalo Tom joins for the debut cover of Taillights Fade. Out Of My Mind is played for the first time since the final Spectrum show in 2009, Ed making the shocking admission that the song doesn’t have set lyrics and that he just makes them up. Another Red Sox jersey is thrown at Mike during the Alive solo, but he doesn’t miss a beat and wears it on his shoulder for a few seconds before tossing it on a mic stand.